Prior Arguments Supporting the Bacterial Pathogenesis What Does the Pathology of Sarcoid

WHAT DOES THE PATHOLOGY OF SARCOID GRANULOMA TELL US? sarcoidosis patients, achieving remissions both of cutaneous lesions and pulmonary manifestations of the disease. Similarities between Tuberculosis and Sarcoidosis have caused researchers to suspect a mycobacterial Finally, Moller and Chen presented persuasive pathogenesis since, at least, Guy Scadding's arguments [6] based, in part, on communication of Bradshaw Lecture in 1949 [1]. Attempts at using antisarcoidosis during transplant surgery, both from a tuberculosis medications however, have been largely sarcoidosis patient to one previously without the unsuccessful (for reasons that will be explained disease, and upon infection spreading into 'clean' below). Du Bois, et al., [2,3] have postulated an tissues implanted into a sarcoidosis patient. etiology where “microbes are a likely trigger (but not as an infection) in a genetically predisposed individual” while Eishi, et al., have suggested that “sarcoidosis may arise from a Th1 immune response to one or more antigens of propionibacteria in an It is commonly believed “the immunologic process individual with a hereditary or acquired abnormality of that leads to sarcoidosis begins when an antigen is the immune system” [4]. presented to a macrophage via HLA class II molecules to a T Lymphocyte. This induces a Th1 TBachelez et al.[5] administered long-term lymphocyte response whereby cytokines are minocycline and/or doxycycline in a cohort of twelve released that result in granuloma formation”[7]. Antibiotics in Sarcoidosis — Reflections on the First Year ©2003 Trevor G Marshall 1 2 Authors: Trevor G Marshall, PhD , and Frances E Marshall, GradDipPharm, RPh